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BETA-CASOMORPHINS - Biological Activity of BCM-7

Gastrointestinal Effects


 

Inhibition of small intestine motility by casein: a role of beta casomorphins?
Defilippi C, Gomez E, Charlin V, Silva C. 1995. Nutrition 119(6):751–754.

Effects of beta-casomorphin derivatives on gastrointestinal transit in mice.
Becker A, Hempel G, Greksch G, Matthies H. (1990) Biomedica Biochimica Acta 49(110):1203–1207.

Beta-casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a mu-opioid pathway.
Zoghbi S, Trompette A, Claustre J, El Homsi M, Garzon J, Jourdain G, Scoazec J,Plaisancie P. 2006. American Journal of Physiology.Gastrointestinal and Liver Physiology 290:G1105–G1113.

Milk bioactive peptides and beta-casomorphins induce mucus release in rat jejunum
Trompette A, Claustre J, Caillon F, Jourdan G, Chayvialle JA, Plaisancié P. (2003) J Nutr. Nov;133(11):3499-503.

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum.
Claustre J, Toumi F, Trompette A, Jourdan G, Guignard H, Chayvialle JA, Plaisancié P. (2002) Am J Physiol Gastrointest Liver Physiol. 3(3):G521-8.

Treatment of acute secretory diarrhea with casein: an effect of beta-casomorphins?][Article in Spanish]
Charlin V, Defilippi C, Vargas V, Borghesi L, Gómez E. (1992) Rev Med Chil. 20(6):666-9.

 

Effects on Immune Cell and Function

 


Pseudoallergic skin reactions to opiate sequences of bovine casein in healthy children
Kurek M, Czerwionka-Szaflarska M, Doroszewska G. 1995.. Rocz Akad Med Bialymst. 40(3):480-5.

A naturally occurring opioid peptide from cow's milk, beta casomorphine-7, is a direct histamine releaser in man.
Kurek M, Przybilla B, Hermann K, Ring J. 1992.. Int Arch Allergy Immunol. 97(2):115-20.

The effects of Casomorphine-7 on NOD mouse macrophage oxidation and primary immune response
American Diabetes Association 58th Annual Meeting and Scientific Session, Chicago 1998

Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.
Kayser H, Meisel H. FEBS Lett. 1996 Mar 25;383(1-2):18-20.


Respiratory Effects

 

Relation of beta-casomorphin to Apnea in Sudden Infant Death Syndrome
Sun Z, Zhang Z, Wang X, Cade R, Elmir Z, Fregly M. 2003.. Peptides 24(6):937-943.

beta-Casomorphins induce apnea and irregular breathing in adult rats and newborn rabbits.
Hedner J, Hedner T. 1987 Life Sci 41(20):2303-12.

Effect of beta-casomorphin on neonatal sleep in rats.
Taira T, Hilakivi LA, Aalto J, Hilakivi I. 1990. Peptides 11(1):1–4.

 

Behavioral & Endocrinological Effects

 

Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
Herrera-Marschitz M, Terenius L, Grehn L, Ungerstedt U.. 1989. Psychopharmacology (Berl).99(3):357-61

Delayed behavioral effects of beta-casomorphin-7 depend on age and gender of albino rat pups.
Dubynin VA, Malinovskaya IV, Ivleva YA, Andreeva LA, Kamenskii AA, Ashmarin, IP 2000. . Bull. Exp. Biol. Med. 130(11), pp1031-1034.

Casein, a prohormone with an immunomodulating role for the newborn?
Migliore-Samour D, Jolles P. Experientia. 1988 Mar 15;44(3):188-93. Review.

Casomorphins reduce separation distress in chicks.
Panksepp J, Normansell L, Siviy S, Rossi J 3rd, Zolovick AJ.1984 Peptides 5(4):829-31

Effects of intra-abomasal infusion of beta-casomorphins on circulating concentrations of hyperglycaemic insulin and glucose in dairy cows.
Kim TG, Choung JJ, Wallace RJ, Chamberlain DG. 1: Comp Biochem Physiol A Mol Integr Physiol. 2000 Nov;127(3):249-57.

Effect of beta-casomorphins on somatostatin release in dogs.
Schusdziarra V, Schick R, de la Fuente A, Holland A, Brantl V, Pfeiffer EF. (1983) Endocrinology. Jun;112(6):1948-51.

Effect of beta-casomorphins and analogs on insulin release in dogs.
Schusdziarra V, Schick A, de la Fuente A, Specht J, Klier M, Brantl V, Pfeiffer EF. 1: Endocrinology. 1983 Mar;112(3):885-9.