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BETA-CASEIN PEPTIDES LINKED TO SYMPTOMS OF NEUROLOGICAL CONDITIONS

Human Studies


 

Milk containing beta-casein with proline at position 67 does not aggravate neurological disorders.
Crawford RA, Boland MJ, Norris CS, Hill JP, Fenwick RM. 2002, PCT WO0219832.

Autism and urinary exogenous neuropeptides: development of an online SPE–HPLC–tandem mass spectrometry method to test the opioid excess theory.
Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. 2007. Analytical and Bioanalytical Chemistry. (Advance online publication May 2007. DOI 10.1007/s00216-007-1301-4).

Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?
Reichelt KL, Knivsberg AM. (2003) Nutritional Neuroscience 6(1):19-28.

Autism and Schizophrenia: Intestinal Disorders.
Cade R et al. (2000) Nutritional Neuroscience 3: 57-72.

Reports on dietary intervention in autistic disorders.
Knivsber AM, Reichelt KL, Nodland M. (2001). Nutritional Neuroscience. 4(1):25-37

A randomised, controlled study of dietary intervention in autistic syndromes.
Knivsberg AM, Reichelt KL, Høien T, Nødland M. (2002). Nutritional Neuroscience 5(4):251-61hin-Dusting J, Shennan J, Jones E, Williams C, Kingwell B, Dart A. (2006) Br J Nutr. 95(1):136-44

The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial.
Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill L. 2006. Journal of Autism and Developmental Disorders 36(3):413 420.

Elimination diets in autism spectrum disorders: any wheat amongst the chaff?
Christison GW, Ivany K. 2006. Journal of Developmental & Behavioral Pediatrics. 27(2Suppl):S162–171.

 

 

Animal Studies and Mechanistic Support

 

Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
Herrera-Marschitz M, Terenius L, Grehn L, Ungerstedt U.. 1989. Psychopharmacology (Berl).99(3):357-61

ß-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism.
Zhongjie Sun, J. Robert Cade, Melvin J. Fregly, R. Malcolm Privette. University of Florida, USA. Autism, Vol. 3, No. 1, 67-83 (1999).

In vitro penetration of des-tyrosine1-D-phenylalanine3-beta-casomorphin across the blood-brain barrier.
Stark H, Van Bree JB, de Boer AG, Jaehde U, Breimer DD. (1992) Peptides. 13(1):47-51.

Saturable transport of peptides across the blood-brain barrier.
Banks WA, Kastin AJ. (1987) Life Sci. 41(11):1319-38.