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Beta-casomorphins - Production & absorption of BCM-7

Unravelled facets of milk derived opioid peptides: a focus on gut physiology, fractures and obesity.

Aslam H, Ruusunen A, Berk M, Loughman A, Rivera L, Pasco JA, et al. Int J Food Sci Nutr. 2020;71(1):36-49.


Degradation of β-casomorphin-7 through in vitro gastrointestinal and jejunal brush border membrane digestion.

Asledottir T, Picariello G, Mamone G, Ferranti P, Røseth A, Devold TG, et al.J Dairy Sci. 2019;102(10):8622-9.

Release of β-casomorphin-7 from bovine milk of different β-casein variants after ex vivo gastrointestinal digestion. 

Asledottir T, Le TT, Poulsen NA, Devold TG, Larsen LB, Vegarud GE. International dairy journal. 2018;81:8-11.

Identification of bioactive peptides and quantification of β-casomorphin-7 from bovine β-casein A1, A2 and I after ex vivo gastrointestinal digestion.

Asledottir T, Le TT, Petrat-Melin B, Devold TG, Larsen LB, Vegarud GE. International Dairy Journal. 2017;71:98-106.

The effect of endurance exercise on intestinal integrity in well-trained healthy men.

JanssenDuijghuijsen LM, Mensink M, Lenaerts K, Fiedorowicz E; Protégé study group, van Dartel DA, Mes JJ, Luiking YC, Keijer J, Wichers HJ, Witkamp RF, van Norren K.

Physiol Rep. 2016 Oct;4(20).


Clinical evaluation of glutathione concentrations after consumption of milk containing different subtypes of β-casein: results from a randomized, cross-over clinical trial.

Deth R, Clarke A, Ni J, Trivedi M. Nutr J. 2016 Sep 29;15(1):82.


Glucose and calcium ions may modulate the efficiency of bovine β-casomorphin-7 permeability through a monolayer of Caco-2 cells.
Jarmołowska B, Teodorowicz M, Fiedorowicz E, Sienkiewicz-Szłapka E, Matysiewicz M, Kostyra E. Peptides. 2013 Nov;49:59-67.

Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans.
Boutrou R, Gaudichon C, Dupont D, Jardin J, Airinei G, Marsset-Baglieri A, Benamouzig R, Tomé D, Leonil J. Am J Clin Nutr. 2013 Jun;97(6):1314-23.

Enzymatic release of neocasomorphin and beta-casomorphin from bovine beta-casein.
Jinsmaa, Y & Yoshikawa, M. (1999). Peptides V20(8), pp 957-962.

ß-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism.
Sun Z, Cade JR, Fregly MJ, Privette RM. Autism. 1999;3(1):67-83.

Casein peptide release and passage to the blood in humans during digestion of milk or yogurt
Chabance B, Marteau P, Rambaud JC, Migliore-Samour D, Boynard M, Perrotin P, Guillot R, Jolles P, Fiat AM 1998.. Biochimie 80(2), pp 155-165.

beta-Casomorphin-immunoreactivity in the brain stem of the human infant.
Pasi A, Mahler H, Lansel N, Bernasconi C, Messiha FS.1993 Res Commun Chem Pathol Pharmacol. 80(3):305-22.

In vitro penetration of des-tyrosine1-D-phenylalanine3-beta-casomorphin across the blood-brain barrier.
Stark H, Van Bree JB, de Boer AG, Jaehde U, Breimer DD. (1992) Peptides. 13(1):47-51.

Saturable transport of peptides across the blood-brain barrier.
Banks WA, Kastin AJ. (1987) Life Sci. 41(11):1319-38.

Demonstration of beta-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans.
Svedberg J, de Haas J, Leimenstoll G, Paul F, Teschemacher H. Peptides. 1985 Sep-Oct;6(5):825-30.

Demonstration of a beta-casomorphin immunoreactive material in the plasma of newborn calves after milk intake.
Umbach M, Teschemacher H, Praetorius K, Hirschhauser R, Bostedt H. 1985. Regul Pept. Nov 7;12(3):223- 30.

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